Research Articles
Predicting Cardiac Gene Regulation with MatrixCatch: A Guide to TFBS Pair Analysis for Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on using the MatrixCatch algorithm to predict transcription factor binding site (TFBS) pairs that regulate cardiac genes.
LEAP Algorithm for Gene Network Inference: A Complete Guide to Transcription Factor Analysis for Researchers
This comprehensive guide explores the LEAP (Lag-based Expression Analysis for Promoter identification) algorithm for inferring transcription factor (TF) networks from gene expression time-series data.
IRX3 and IRX5 Transcription Factors in Cardiac Development: Molecular Mechanisms, Disease Links, and Therapeutic Potential
This comprehensive review explores the critical roles of Iroquois-class homeobox transcription factors IRX3 and IRX5 in cardiac morphogenesis and function.
HDAC Inhibitors in Cellular Reprogramming: Boosting Efficiency, Overcoming Barriers, and Future Clinical Promise
This article provides a comprehensive guide for researchers on using HDAC inhibitors to enhance cellular reprogramming efficiency.
H3K4me3 vs. H3K27me3: The Bivalent Chromatin Switch Controlling Cell Fate Decisions in Development and Disease
This article explores the critical balance between the activating histone mark H3K4me3 and the repressive mark H3K27me3 in regulating cell identity and fate decisions.
Live-Cell Imaging of Chromosome Dynamics: H2B-mCherry Labeling in Preimplantation Blastocysts
This article provides a comprehensive guide to utilizing H2B-mCherry fluorescent labeling for tracking chromosome dynamics and cell division in mouse and human preimplantation blastocysts.
Decoding the French Flag Model: How Positional Information Drives Biomedical Discovery and Drug Development
This article provides a comprehensive analysis of the French Flag Model, a foundational concept in developmental biology, for researchers and drug development professionals.
Unlocking Cell Fate: A Comprehensive Guide to FUCCI Cell Cycle Synchronized Differentiation
This article provides researchers, scientists, and drug development professionals with a complete roadmap for the FUCCI (Fluorescent Ubiquitination-based Cell Cycle Indicator) reporter system.
FRAP for Morphogen Diffusion Analysis: Protocols, Optimization, and Advanced Applications in Biomedical Research
This comprehensive guide explores Fluorescence Recovery After Photobleaching (FRAP) as a cornerstone technique for quantifying morphogen diffusion kinetics in biological systems.
Choosing the Best Fixative: Dent's vs Paraformaldehyde for Embryo Immunostaining
This comprehensive guide provides researchers and drug development professionals with a critical analysis of two primary fixation methods for embryo immunostaining: Dent's fixative and paraformaldehyde (PFA).